Experimental studies highlight profound effects of sleep disruptions on pain, showing that sleep deprivation (SD) leads to hyperalgesic pain changes. On the other hand, given that sleep helps normalizing bodily functions, a crucial role of restorative sleep in the overnight restoration of the pain system seems likely. Thus, a systematic review of experimental studies on effects of recovery sleep (RS; subsequently to SD) on pain was performed with the aim to check whether RS resets hyperalgesic pain changes occurring due to SD. Empirical animal and human studies including SD-paradigms, RS and pain assessments were searched in three databases (PubMed, Web of Science, PsycINFO) using a predefined algorithm. 29 studies were included in this review. Most results indicated a reset of enhanced pain sensitivity and vulnerability following RS, especially when total SD was implemented and pressure pain or painful symptoms (human studies) were assessed. Further research should focus on whether and how recovery is altered in chronic pain patients, as this yields implications for pain treatment by enhancing or stabilizing RS.

中文翻译：

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恢复睡眠对疼痛知觉的影响：系统评价。

实验研究强调了睡眠中断对疼痛的深远影响，表明睡眠剥夺（SD）会导致痛觉过敏性疼痛改变。另一方面，考虑到睡眠有助于身体机能正常化，恢复性睡眠在夜间疼痛系统恢复中的关键作用似乎很重要。因此，对恢复性睡眠（RS；继之以SD）对疼痛的影响进行实验研究的系统综述，旨在检查RS是否能复位由于SD引起的痛觉过敏性疼痛变化。使用预定义算法，在三个数据库（PubMed，Web of Science，PsycINFO）中搜索了包括SD范式，RS和疼痛评估在内的动物和人类经验研究。该评价纳入29项研究。大多数结果表明，RS后疼痛敏感性和脆弱性有所增强，尤其是在实施总SD并评估了压痛或疼痛症状（人体研究）时。进一步的研究应集中于慢性疼痛患者是否以及如何改变恢复，因为这通过增强或稳定RS对疼痛治疗产生影响。