Most mental disorders are now considered to have neurodevelopmental origins, with a growing body of research pointing to neural alterations that predate birth. However, lack of established methods for reliable investigation of fetal brain development has limited research into early neural vulnerability. Using a systematic approach and quantitative evaluation of study methodology, we review neurosonographic studies of fetal brain structure with objective quality measures. A total of 81 studies were identified. High quality studies were identified for measurement of the corpus callosum, cerebellum, vermis, ventricles and frontal cortex, with reference ranges provided to facilitate future clinical research. Fewer and lower quality studies were available for subcortical structures, prompting a need for further research to create reliable reference ranges. Development and adoption of reference ranges for fetal brain structures should facilitate future research in neurosonographic evaluation of fetal brain development and lead to a better understanding of neurodevelopmental risk and resilience processes for mental disorders.

中文翻译：

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胎儿神经超声检查方法学综述：评估精神健康问题的神经发育风险的新方向。

现在，大多数精神障碍都被认为具有神经发育起源，越来越多的研究指出了出生之前的神经改变。但是，缺乏可靠的胎儿大脑发育研究方法已经缺乏对早期神经易感性的研究。使用系统的方法和研究方法的定量评估，我们用客观的质量措施回顾了胎儿脑结构的超声检查。总共确定了81个研究。确定了用于测量were体，小脑，ver骨，心室和额叶皮层的高质量研究，并提供了参考范围以方便将来的临床研究。皮质下结构的研究较少且质量较低，促使需要进一步研究以创建可靠的参考范围。胎儿脑结构参考范围的开发和采用应促进胎儿脑发育的神经超声评估的未来研究，并有助于更好地理解精神障碍的神经发育风险和适应力过程。