当前位置: X-MOL 学术Food Biosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Motion sickness-relieving effects of Tamzin, a herbal formulation: In vitro and in vivo studies
Food Bioscience ( IF 4.8 ) Pub Date : 2020-04-08 , DOI: 10.1016/j.fbio.2020.100595
N. Ilaiyaraja , Dongzagin Singsit , Mahantesh M Patil , S. Priyadharshini , V. Rashmi , Farhath Khanum

A herbal formulation (Tamzin) based on ginger and tamarind in combination with other natural ingredients for relieving motion sickness was studied. The proximate composition, polyphenols and vitamins content of the product were determined. The average values for moisture, carbohydrate, crude protein, fat, ash and crude fiber were 3.9, 85, 5.9, 1.4, 1.7 and 1.8%, respectively. In general, the sensory characteristics of both fresh and 6 month stored products had overall acceptability values of 8.5 and 7.9, respectively, on a 9-point hedonic scale. Seven-day oral administration of Tamzin aqueous extract (TE) to BALB/c mice significantly reduced the rotation-induced gastrointestinal symptoms such as conditioned gaping, defecation levels and locomotion activity. The extract also inhibited the histamine release in KU812 cells and showed no adverse effect up to 5 mg/mL concentration measured using 3-(4,5-dimethyl-2-yl)-2,5-diphenyltetrazolium bromide and lactate dehydrogenase leakage assays. The study showed that the formulation can provide beneficial health effects in alleviating symptoms caused by motion-sickness.



中文翻译:

Tamzin(一种草药制剂)的晕车缓解作用:体外体内研究

研究了基于生姜和罗望子树与其他天然成分的缓解晕动病的草药制剂(坦赞)。测定产品的最接近组成,多酚和维生素含量。水分,碳水化合物,粗蛋白,脂肪,灰分和粗纤维的平均值分别为3.9%,85%,5.9%,1.4%,1.7%和1.8%。通常,在9点享乐量表上,新鲜和6个月存储产品的感官特性分别具有8.5和7.9的总体可接受度。对BALB / c小鼠口服Tamzin水提取物(TE)7天,可显着减轻旋转诱导的胃肠道症状,例如条件性的开裂,排便水平和运动活动。该提取物还抑制KU812细胞中组胺的释放,使用3-(4,5-二甲基-2-基)-2,5-二苯基溴化四溴甲烷和乳酸脱氢酶渗漏法测定,浓度最高至5 mg / mL时,没有显示出不良反应。研究表明,该制剂可以减轻晕车引起的症状,对健康有益。

更新日期:2020-04-08
down
wechat
bug