Aberrant metabolism is a key factor in many neurological disorders. The ability to measure such metabolic impairment could lead to improved detection of disease progression, and development and monitoring of new therapeutic approaches. Hyperpolarized 13C magnetic resonance spectroscopy (MRS) is a developing imaging technique that enables non-invasive measurement of enzymatic activity in real time in living organisms. Primarily applied in the fields of cancer and cardiac disease so far, this metabolic imaging method has recently been used to investigate neurological disorders. In this review, we summarize the preclinical research developments in this emerging field, and discuss future prospects for this exciting technology, which has the potential to change the clinical paradigm for patients with neurological disorders.

中文翻译：

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使用超极化 13C 磁共振光谱成像脑代谢

异常代谢是许多神经系统疾病的关键因素。测量这种代谢障碍的能力可以改善对疾病进展的检测，以及新治疗方法的开发和监测。超极化 13C 磁共振波谱 (MRS) 是一种发展中的成像技术，可以对活生物体中的酶活性进行实时非侵入性测量。迄今为止，这种代谢成像方法主要应用于癌症和心脏病领域，最近已用于研究神经系统疾病。在这篇综述中，我们总结了这一新兴领域的临床前研究进展，并讨论了这项激动人心的技术的未来前景，它有可能改变神经系统疾病患者的临床范式。