Ubiquitin C‐terminal hydrolase 1 (UCHL1) is an enzyme unique for its multiple activity – both ligase and hydrolase. UCHL1 was first identified as an abundant protein found in the brain and testes, however its expression is not limited to the neuronal compartment. UCHL1 is also highly expressed in carcinomas of various tissue origins, including those from brain, lung, breast, kidney, colon, prostate, pancreas and mesenchymal tissues. Loss‐of‐function studies and an inhibitor for UCHL1 confirmed the importance of UCHL1 for cancer therapy. So far biological significance of UCHL1 was described in the following processes: spermatogenesis, oncogenesis, angiogenesis, cell proliferation and differentiation in skeletal muscle, inflammation, tissue injury, neuronal injury and neurodegeneration.

中文翻译：

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泛素羧基末端水解酶L1 –生理和病理学

泛素C末端水解酶1（UCHL1）是一种具有多种活性的独特酶-连接酶和水解酶。UCHL1首先被鉴定为在大脑和睾丸中发现的一种丰富的蛋白质，但是其表达并不局限于神经元区室。UCHL1在各种组织起源的癌中也高表达，包括来自脑，肺，乳腺，肾脏，结肠，前列腺，胰腺和间质组织的癌。功能丧失研究和UCHL1抑制剂证实了UCHL1在癌症治疗中的重要性。到目前为止，UCHL1的生物学意义已通过以下过程进行了描述：精子发生，肿瘤发生，血管生成，骨骼肌细胞增殖和分化，炎症，组织损伤，神经元损伤和神经变性。