Long non‐coding RNA (lncRNA) LINC00899 is one kind cytoplasmic lncRNA, however, there is rarely little information about its function in physiological process. Here, we demonstrated that lncRNA LINC00899 was upregulated in acute myeloid leukaemia (AML) cells and was quite correlated with poor prognosis of AML patients. High expression of LINC00899 in AML cells could promote cell proliferation and inhibit cell apoptosis, and facilitate the progression of AML consequently both in vitro and in vivo. Besides, LINC00899 acted as a molecular sponge of miR‐744‐3p. Furthermore, we characterized YY1 as the direct target of miR‐744‐3p, and LINC00899/miR‐744‐3p interaction modulated YY1 expression in AML cells. Finally, we verified LINC00899 modulated AML cell proliferation and apoptosis via regulating YY1. Our study revealed novel mechanism about how did lncRNA LINC00899 execute function in AML and thus provided potential therapeutic interventions for AML.

中文翻译：

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LncRNA LINC00899通过调节miR‐744‐3p / YY1信号传导促进急性髓细胞白血病的进展

长非编码RNA（lncRNA）LINC00899是一种细胞质lncRNA，但是，关于其在生理过程中的功能的信息很少。在这里，我们证明了lncRNA LINC00899在急性髓细胞性白血病（AML）细胞中上调，并且与AML患者的不良预后密切相关。LINC00899在AML细胞中的高表达可促进细胞增殖并抑制细胞凋亡，并因此在体外和体内促进AML的发展。此外，LINC00899充当miR‐744‐3p的分子海绵。此外，我们将YY1表征为miR-744-3p的直接靶标，并且LINC00899 / miR-744-3p相互作用调节了AML细胞中YY1的表达。最后，我们验证了LINC00899通过调节YY1调节了AML细胞的增殖和凋亡。