Multiscale modeling of vertebrate limb development.,WIREs Mechanisms of Disease

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Multiscale modeling of vertebrate limb development.
WIREs Mechanisms of Disease ( IF 4.6 ) Pub Date : 2020-03-24 , DOI: 10.1002/wsbm.1485
Tilmann Glimm ₁ , Ramray Bhat ₂ , Stuart A Newman ₃

Affiliation

We review the current state of mathematical modeling of cartilage pattern formation in vertebrate limbs. We place emphasis on several reaction–diffusion type models that have been proposed in the last few years. These models are grounded in more detailed knowledge of the relevant regulatory processes than previous ones but generally refer to different molecular aspects of these processes. Considering these models in light of comparative phylogenomics permits framing of hypotheses on the evolutionary order of appearance of the respective mechanisms and their roles in the fin‐to‐limb transition.

中文翻译：

脊椎动物肢体发育的多尺度建模。

我们回顾了脊椎动物四肢软骨模式形成的数学建模的现状。我们将重点放在过去几年中提出的几种反应扩散型模型上。这些模型基于对相关监管过程的更详细了解，但通常涉及这些过程的不同分子方面。根据比较系统基因组学考虑这些模型，可以对各个机制出现的进化顺序及其在鳍到肢过渡中的作用提出假设。

更新日期：2020-03-24

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