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Contaminated and misidentified cell lines commonly use in cancer research.
Molecular Carcinogenesis ( IF 3.0 ) Pub Date : 2020-03-20 , DOI: 10.1002/mc.23189
Siu Tim Cheung 1, 2 , Stephen L Chan 3 , Kwok Wai Lo 4
Affiliation  

Cell line authentication is important for credibility concern and scientific reproducibility. Authenticated cancer cell lines retain the properties of the cancers of origin and serve valuable resources for medical research. Experimental results commonly will be validated in more than one cell line to avoid specific cell line effect not generalizable to the disease on the whole. The use of appropriate and verified cell lines would therefore be very important in preclinical studies of translational research, bridging basic research to clinics.

中文翻译:

受污染和错误识别的细胞系通常用于癌症研究。

细胞系认证对于可信度关注和科学再现性至关重要。经过身份验证的癌细胞系保留了起源癌症的特性,并为医学研究提供了宝贵的资源。通常将在不止一种细胞系中验证实验结果,以避免整体上无法推广到该疾病的特定细胞系效应。因此,在转化研究的临床前研究中将适当的经过验证的细胞系的使用非常重要,从而将基础研究与临床联系起来。
更新日期:2020-03-20
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