Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting females of reproductive age. It has been associated with cardiometabolic disorders including diabetes mellitus and cardiovascular disorders, and increases the risk of developing fecundity pathologies including recurrent pregnancy loss (RPL) and infertility. C1q/tumor necrosis factor‐α‐related protein‐6 (CTRP6) is a novel adipokine involved in glucose and lipid metabolism, host inflammation, and organogenesis. In the present study, we aimed to determine the association of serum CTRP6 levels with some components of metabolic syndrome in PCOS patients (infertile PCOS [inf‐PCOS] and PCOS‐RPL). This case–control study included 120 PCOS patients (60 inf‐PCOS and 60 PCOS‐RPL) and 60 healthy controls. Serum high‐sensitivity C‐reactive protein (hs‐CRP) and homocysteine were measured using commercial kits, while adiponectin and CTRP6 levels were assessed using ELISA technique. Inf‐PCOS and PCOS‐RPL individuals had higher levels of serum CTRP6 than controls (546.15 ± 125.02 ng/ml and 534.04 ± 144.19 ng/ml vs. 440.16 ± 159.24 ng/ml; both p < .001). Moreover, serum adiponectin levels were significantly reduced, while fasting insulin, homeostasis model assessment of insulin resistance, free testosterone, and hs‐CRP levels were significantly elevated in PCOS group, when compared with controls. Furthermore, serum CTRP6 positively associated with body mass index in all subjects. It showed an inverse correlation with adiponectin in PCOS group and subgroups. However, it had a direct association with hs‐CRP in PCOS group and inf‐PCOS subgroup, but not PCOS‐RPL subgroup. These findings unravel a probable role of CTRP6 in PCOS pathogenesis, which poses a possibility to be a good diagnostic target. However, further investigation is needed.

中文翻译：

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C1q/TNF-α相关蛋白6（CTRP6）在多囊卵巢综合征中的循环水平

多囊卵巢综合征 (PCOS) 是影响育龄女性的最常见内分泌疾病之一。它与包括糖尿病和心血管疾病在内的心脏代谢疾病有关，并增加了发生生殖疾病的风险，包括复发性流产 (RPL) 和不孕症。C1q/肿瘤坏死因子-α-相关蛋白-6 (CTRP6) 是一种新型脂肪因子，参与葡萄糖和脂质代谢、宿主炎症和器官发生。在本研究中，我们旨在确定血清 CTRP6 水平与 PCOS 患者（不育 PCOS [inf-PCOS] 和 PCOS-RPL）代谢综合征的某些成分之间的关​​联。该病例对照研究包括 120 名 PCOS 患者（60 名 inf-PCOS 和 60 名 PCOS-RPL）和 60 名健康对照。使用商业试剂盒测量血清高敏 C 反应蛋白 (hs-CRP) 和同型半胱氨酸，而使用 ELISA 技术评估脂联素和 CTRP6 水平。Inf-PCOS 和 PCOS-RPL 个体的血清 CTRP6 水平高于对照组（546.15 ± 125.02 ng/ml 和 534.04 ± 144.19 ng/ml vs. 440.16 ± 159.24 ng/ml；两者 p < .001）。此外，与对照组相比，PCOS 组的血清脂联素水平显着降低，而空腹胰岛素、胰岛素抵抗的稳态模型评估、游离睾酮和 hs-CRP 水平显着升高。此外，血清 CTRP6 与所有受试者的体重指数呈正相关。它与PCOS组和亚组中的脂联素呈负相关。然而，它与 PCOS 组和 inf-PCOS 亚组中的 hs-CRP 直接相关，但不是 PCOS-RPL 亚组。这些发现揭示了 CTRP6 在 PCOS 发病机制中的可能作用，这有可能成为一个很好的诊断目标。但是，还需要进一步调查。