Quercetin prevents alterations of behavioral parameters, delta‐aminolevulinic dehydratase activity and oxidative damage in brain of rats in a prenatal model of autism,International Journal of Developmental Neuroscience

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Quercetin prevents alterations of behavioral parameters, delta‐aminolevulinic dehydratase activity and oxidative damage in brain of rats in a prenatal model of autism
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-04-22 , DOI: 10.1002/jdn.10025
Bruna da Silveira de Mattos ₁ , Mayara Sandrielly Pereira Soares ₁ , Luiza Spohr ₁ , Nathalia Stark Pedra ₁ , Fernanda Cardoso Teixeira ₁ , Anita Avila de Souza ₁ , Francieli Moro Stefanello ₂ , Jucimara Baldissarelli ₁ , Giovana Duzzo Gamaro ₁ , Roselia Maria Spanevello ₁

Affiliation

Autism is a neuropathology characterized by behavioral disorders. Considering that oxidative stress is involved in the pathophysiology of this disease, we evaluated the effects of quercetin, a flavonoid with antioxidant and neuroprotective properties, in an experimental model of autism induced by valproic acid (VPA). Twelve pregnant female rats were divided into four groups (control, quercetin, VPA, and VPA+quercetin). Quercetin (50 mg/kg) was administered orally to the animals from gestational days 6.5 to 18.5, and VPA (800 mg/kg) was administered orally in a single dosage on gestational day 12.5. Behavioral tests such as open field, social interaction, and tail flick nociceptive assays were performed on pups between 30 and 40 days old, after which the animals were euthanized. Cerebral cortex, hippocampus, striatum, and cerebellum were collected for evaluation of oxidative stress parameters. The pups exposed to VPA during the gestational period showed reduced weight gain, increased latency in the open field and tail flick tests, reduced time of social interaction, accompanied by changes in oxidative stress parameters mainly in the hippocampus and striatum. Prenatal treatment with quercetin prevented the behavioral changes and damage caused by oxidative stress, possibly due to its antioxidant action. Our findings demonstrated that quercetin has neuroprotective effects in an animal model of autism, suggesting that this natural molecule could be an important therapeutic agent for treatment of autism spectrum disorders (ASDs).

中文翻译：

槲皮素预防自闭症产前模型大鼠大脑中行为参数、δ-氨基乙酰丙酸脱水酶活性和氧化损伤的改变

自闭症是一种以行为障碍为特征的神经病理学。考虑到氧化应激与这种疾病的病理生理有关，我们评估了槲皮素（一种具有抗氧化和神经保护特性的黄酮类化合物）在丙戊酸 (VPA) 诱导的自闭症实验模型中的作用。将 12 只怀孕雌性大鼠分为四组（对照组、槲皮素、VPA 和 VPA+槲皮素）。从妊娠第 6.5 天至第 18.5 天口服给予动物槲皮素 (50 毫克/千克)，并在妊娠第 12.5 天以单剂量口服给药 VPA (800 毫克/千克)。对 30 至 40 天大的幼崽进行行为测试，例如露天场地、社交互动和甩尾伤害性试验，然后对动物实施安乐死。大脑皮层、海马、纹状体、收集小脑和小脑用于评估氧化应激参数。妊娠期暴露于 VPA 的幼崽表现出体重增加减少、旷场和甩尾测试潜伏期增加、社交时间减少，伴随着主要在海马和纹状体中氧化应激参数的变化。槲皮素的产前治疗可防止氧化应激引起的行为改变和损害，这可能是由于其抗氧化作用。我们的研究结果表明，槲皮素在自闭症动物模型中具有神经保护作用，表明这种天然分子可能是治疗自闭症谱系障碍 (ASD) 的重要治疗剂。旷场和甩尾测试中的潜伏期增加，社交互动时间减少，伴随着主要在海马体和纹状体中的氧化应激参数的变化。槲皮素的产前治疗可防止氧化应激引起的行为改变和损害，这可能是由于其抗氧化作用。我们的研究结果表明，槲皮素在自闭症动物模型中具有神经保护作用，表明这种天然分子可能是治疗自闭症谱系障碍 (ASD) 的重要治疗剂。旷场和甩尾测试中的潜伏期增加，社交互动时间减少，伴随着主要在海马体和纹状体中的氧化应激参数的变化。槲皮素的产前治疗可防止氧化应激引起的行为改变和损害，这可能是由于其抗氧化作用。我们的研究结果表明，槲皮素在自闭症动物模型中具有神经保护作用，表明这种天然分子可能是治疗自闭症谱系障碍 (ASD) 的重要治疗剂。可能是因为它的抗氧化作用。我们的研究结果表明，槲皮素在自闭症动物模型中具有神经保护作用，表明这种天然分子可能是治疗自闭症谱系障碍 (ASD) 的重要治疗剂。可能是因为它的抗氧化作用。我们的研究结果表明，槲皮素在自闭症动物模型中具有神经保护作用，表明这种天然分子可能是治疗自闭症谱系障碍 (ASD) 的重要治疗剂。

更新日期：2020-04-22

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