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Definitive-intent radiotherapy for sinonasal carcinoma in cats: A multicenter retrospective assessment.
Veterinary and Comparative Oncology ( IF 2.3 ) Pub Date : 2020-03-05 , DOI: 10.1111/vco.12583
Katerina Stiborova 1 , Valeria S Meier 1, 2 , Marilia Takada 3 , Michelle Turek 3 , Valerie J Poirier 4 , Sarah Laliberte 4 , Carla Rohrer Bley 1
Affiliation  

Treatment of epithelial sinonasal tumours in cats is not commonly reported. In the newer reports, palliative radiation protocols have been described more often than definitive‐intent protocols. In this multi‐institutional retrospective study, we included 27 cats treated with single‐modality radiotherapy. Cats were irradiated using 10 daily fractions of 4.2 Gy. Three cats (11.1%) experienced a complete clinical response and 17 (63%) had a partial clinical response. Stable clinical disease was noted in three cats (11.1%). Four cats (14.8%) showed progression within 3 months following treatment. The median time to progression for all cases was 269 days (95 % confidence intervals [CI]: 225; 314). The proportion of cats free of progression at 1 and 2 years was 24% (95% CI: 22%; 26%) and 5% (95% CI: 5%; 6%), respectively. None of the prognostic factors evaluated were predictive of outcome (anaemia, tumour volume at the time of staging, modified Adams stage, intracranial involvement, facial deformity, epistaxis, inappetence or weight loss). Median overall survival (OS) for all deaths was 452 days (95% CI: 334; 571). The proportion of cats alive at 1 and 2 years was 57% (95% CI: 37%; 77%) and 27% (95% CI: 25%; 29%), respectively. Surprisingly, cats with epistaxis had a longer median OS of 828 days (95% CI: 356; 1301) compared to 296 days (95% CI: 85; 508) in cats without epistaxis, (P = .04, Breslow). Radiation therapy used as a single modality for the treatment of feline sinonasal carcinoma improved clinical signs and was well tolerated but progression within a year was common.

中文翻译:

猫鼻窦癌的明确放射治疗:多中心回顾性评估。

猫上皮性鼻窦肿瘤的治疗并不常见。在较新的报告中,姑息性放疗方案的描述比明确的意向方案更频繁。在这项多机构回顾性研究中,我们纳入了 27 只接受单模式放疗的猫。每天使用 10 次 4.2 Gy 对猫进行照射。三只猫 (11.1%) 出现了完全的临床反应,17 只 (63%) 出现了部分临床反应。三只猫(11.1%)观察到稳定的临床疾病。四只猫 (14.8%) 在治疗后 3 个月内出现进展。所有病例的中位进展时间为 269 天(95% 置信区间 [CI]:225;314)。1 年和 2 年无进展的猫比例分别为 24%(95% CI:22%;26%)和 5%(95% CI:5%;6%)。评估的预后因素均不能预测结果(贫血、分期时的肿瘤体积、改良的 Adams 分期、颅内受累、面部畸形、鼻衄、食欲不振或体重减轻)。所有死亡的中位总生存期 (OS) 为 452 天(95% CI:334;571)。1 年和 2 年存活的猫比例分别为 57%(95% CI:37%;77%)和 27%(95% CI:25%;29%)。令人惊讶的是,与没有鼻衄的猫的 296 天(95% CI:85;508)相比,有鼻衄的猫的中位 OS 更长,为 828 天(95% CI:356;1301),(1 年和 2 年存活的猫比例分别为 57%(95% CI:37%;77%)和 27%(95% CI:25%;29%)。令人惊讶的是,与没有鼻衄的猫的 296 天(95% CI:85;508)相比,有鼻衄的猫的中位 OS 更长,为 828 天(95% CI:356;1301),(1 年和 2 年存活的猫比例分别为 57%(95% CI:37%;77%)和 27%(95% CI:25%;29%)。令人惊讶的是,与没有鼻衄的猫的 296 天(95% CI:85;508)相比,有鼻衄的猫的中位 OS 更长,为 828 天(95% CI:356;1301),(P = .04,布雷斯洛)。放疗作为一种治疗猫鼻窦癌的单一方式改善了临床症状,耐受性良好,但一年内进展很常见。
更新日期:2020-03-05
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