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Sleep disorders in myotonic dystrophies.
Muscle & Nerve ( IF 2.8 ) Pub Date : 2020-03-25 , DOI: 10.1002/mus.26866
Sub H Subramony 1 , James P Wymer 1 , Belinda S Pinto 2 , Eric T Wang 2
Affiliation  

Myotonic dystrophies (DM), the most common muscular dystrophies, are known to have significant sleep disturbances. We analyzed the literature on sleep and excessive daytime sleepiness (EDS) in DM over the past 30 years. In this review we provide a brief overview of sleep, sleep disorders, and methods of assessment. We also analyze data regarding major sleep disorders in DM patients, including: sleep‐disordered breathing (SDB), with both central and obstructive sleep apneas (CSA,OSA); EDS; sleep‐related movement disorders; and poor sleep quality. We review the possible pathogenesis of these disorders and outline management strategies. We also consider possible future avenues for research. The findings highlight the complex set of sleep‐related problems, including the primary abnormality of sleep control in myotonic dystrophies. In individual patients the roles of poor sleep hygiene, SDB, primary hypersomnia, and excess fatigue require careful assessment for appropriate management.

中文翻译:

强直性肌营养不良症的睡眠障碍。

肌强直性营养不良(DM)是最常见的肌肉营养不良,已知会引起严重的睡眠障碍。我们分析了过去30年中DM中睡眠和白天过度嗜睡(EDS)的文献。在这篇综述中,我们简要概述了睡眠,睡眠障碍和评估方法。我们还分析了有关DM患者的主要睡眠障碍的数据,包括:睡眠呼吸障碍(SDB),中枢性和阻塞性呼吸暂停(CSA,OSA);EDS;睡眠相关的运动障碍; 睡眠质量差 我们回顾了这些疾病的可能发病机理,并概述了治疗策略。我们还考虑了未来可能的研究途径。这些发现突出了与睡眠有关的一系列复杂问题,包括强直性肌营养不良症的主要睡眠控制异常。
更新日期:2020-03-25
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