transmembrane activator and CAML interactor (TACI) protein, also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), is a member of the tumor necrosis factor (TNF)‐like receptor family, a group of receptors that regulate both survival and apoptosis of immune cells. TACI controls T cell‐independent B cell antibody responses, isotype switching, homeostasis, and mediates immunoglobulins production. Common variable immunodeficiency (CVID) is a heterogeneous group of diseases characterized by a hypogammaglobinemia with loss of antibody production and susceptibility to bacterial infections.

中文翻译：

---

TACI突变的三个不同方面。

跨膜激活剂和CAML相互作用蛋白（TACI），也称为肿瘤坏死因子受体超家族成员13B（TNFRSF13B），是类肿瘤坏死因子（TNF）受体家族的成员，该家族可调节生存和凋亡免疫细胞。TACI控制独立于T细胞的B细胞抗体反应，同种型转换，体内稳态并介导免疫球蛋白的产生。普通可变免疫缺陷症（CVID）是一组异质性疾病，其特征在于血红蛋白降低，抗体产生降低和易受细菌感染。