Urocortin 1: A putative excitatory neurotransmitter in the enteric nervous system,Neurogastroenterology & Motility

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Urocortin 1: A putative excitatory neurotransmitter in the enteric nervous system
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-03-20 , DOI: 10.1111/nmo.13842
Shigeru Yamato ₁ , Ayako Kurematsu ₁ , Tomofumi Amano ₁ , Hajime Ariga ₁ , Tetsuya Ando ₂ , Gen Komaki ₂ , Keiji Wada ₃

Affiliation

Urocortin 1 (Ucn1), a stress‐related peptide, is a member of the corticotropin‐releasing factor (CRF) family and acts as a CRF1 receptor agonist. Ucn1 and CRF1 receptor immunoreactivity are present in the enteric nervous system (ENS), and Ucn1 elicits contraction of colonic muscle strips. Considering these findings, we have hypothesized that Ucn1 acts as an excitatory neurotransmitter in the ENS. The present study was conducted to determine whether exogenously applied Ucn1 causes contractions, whether it participates in neurally mediated contraction, and whether it is released from the ENS of the rat colon.

中文翻译：

尿皮质素 1：一种假定的肠神经系统兴奋性神经递质

尿皮质素 1 (Ucn1) 是一种应激相关肽，是促肾上腺皮质激素释放因子 (CRF) 家族的成员，可作为 CRF1 受体激动剂。Ucn1 和 CRF1 受体免疫反应性存在于肠神经系统 (ENS) 中，并且 Ucn1 引起结肠肌条收缩。考虑到这些发现，我们假设 Ucn1 在 ENS 中充当兴奋性神经递质。本研究旨在确定外源性应用的 Ucn1 是否会引起收缩，它是否参与神经介导的收缩，以及它是否从大鼠结肠的 ENS 中释放出来。

更新日期：2020-03-20

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