Stress exacerbates many chronic pain syndromes including irritable bowel syndrome (IBS). Among these patient populations, many suffer from comorbid or chronic overlapping pain conditions and are predominantly female. Nevertheless, basic studies investigating chronic psychological stress‐induced changes in pain sensitivity have been mostly carried out in male rodents. Our laboratory developed a model of comorbid pain hypersensitivity (CPH) (stress in the presence of preexisting orofacial pain inducing chronic visceral pain hypersensitivity that significantly outlasts transient stress‐induced pain hypersensitivity (SIH)) facilitating the study of pain associated with IBS. Since CPH and SIH are phenotypically similar until SIH resolves and CPH persists, it is unclear if underlying mechanisms are similar.

中文翻译：

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周围机制促进了雌性大鼠因先前存在的口面疼痛和压力而诱发的内脏超敏反应。

压力加剧了许多慢性疼痛综合症，包括肠易激综合症（IBS）。在这些患者人群中，许多患者患有合并症或慢性重叠疼痛症状，并且主要为女性。然而，调查慢性心理压力引起的疼痛敏感性变化的基础研究主要是在雄性啮齿动物中进行的。我们的实验室开发了一种共病性疼痛超敏反应（CPH）模型（在存在口面疼痛的情况下可诱发慢性内脏痛超敏反应的压力显着超过短暂性应激诱发的疼痛超敏反应（SIH）），从而促进了与IBS相关的疼痛的研究。由于CPH和SIH在表型上相似，直到SIH解决并且CPH持续存在，因此尚不清楚基本机制是否相似。