The impact of the ancillary pilus‐1 protein RrgA of Streptococcus pneumoniae on colonization and disease,Molecular Microbiology

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The impact of the ancillary pilus‐1 protein RrgA of Streptococcus pneumoniae on colonization and disease
Molecular Microbiology ( IF 2.6 ) Pub Date : 2020-03-17 , DOI: 10.1111/mmi.14451
Federico Iovino ₁ , Priyanka Nannapaneni ₁ , Birgitta Henriques‐Normark _{1,

2,

3} , Staffan Normark _{1,

3}

Affiliation

The Gram‐positive bacterium Streptococcus pneumoniae, the pneumococcus, is an important commensal resident of the human nasopharynx. Carriage is usually asymptomatic, however, S. pneumoniae can become invasive and spread from the upper respiratory tract to the lungs causing pneumonia, and to other organs to cause severe diseases such as bacteremia and meningitis. Several pneumococcal proteins important for its disease‐causing capability have been described and many are expressed on the bacterial surface. The surface located pneumococcal type‐1 pilus has been associated with virulence and the inflammatory response, and it is present in 20%–30% of clinical isolates. Its tip protein RrgA has been shown to be a major adhesin to human cells and to promote invasion through the blood‐brain barrier. In this review we discuss recent findings of the impact of RrgA on bacterial colonization of the upper respiratory tract and on pneumococcal virulence, and use epidemiological data and genome‐mining to suggest trade‐off mechanisms potentially explaining the rather low prevalence of pilus‐1 expressing pneumococci in humans.

中文翻译：

肺炎链球菌辅助菌毛1蛋白RrgA对定植和疾病的影响

对革兰氏阳性菌肺炎链球菌，肺炎双球菌，是一个重要的共生居民人鼻咽部。支架通常无症状，但是，肺炎链球菌会从上呼吸道侵入并扩散到肺，引起肺炎，并扩散到其他器官，引起严重的疾病，例如菌血症和脑膜炎。已经描述了几种对肺炎球菌引起疾病的能力很重要的蛋白质，其中许多在细菌表面表达。位于表面的肺炎球菌1型菌毛与毒力和炎症反应有关，在临床分离株中占20％至30％。它的尖端蛋白RrgA被证明是对人体细胞的主要粘附素，并通过血脑屏障促进侵袭。在这篇综述中，我们讨论了RrgA对上呼吸道细菌定植和肺炎球菌毒力的影响的最新发现，

更新日期：2020-03-26

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