The impact of aging on the subregions of the fusiform gyrus in healthy older adults,Journal of Neuroscience Research

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The impact of aging on the subregions of the fusiform gyrus in healthy older adults
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-03-08 , DOI: 10.1002/jnr.24586
Mahima Shah ₁ , Florian Kurth ₁ , Eileen Luders ₁

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The fusiform gyrus is known to decrease in size with increasing age. However, reported findings are inconsistent and existing studies differ in terms of the cohorts examined and/or the methods applied. Here, we analyzed age‐related links in four distinct subregions of the fusiform gyrus through integrating imaging‐based intensity information with microscopically defined cytoarchitectonic probabilities. In addition to age effects we investigated sex effects as well as age‐by‐sex interactions in a relatively large sample of 468 healthy subjects (272 females/196 males) covering a broad age range (42–97 years). We observed significant negative correlations between age and all four subregions of the fusiform gyrus indicating volume decreases over time, albeit with subregion‐specific trajectories. Additionally, we observed significant negative quadratic associations with age for some subregions, suggesting an accelerating volume loss over time. These findings may serve as a frame of reference for future cross‐sectional as well as longitudinal studies, not only for normative samples but also potentially for clinical conditions that present with abnormal atrophy of the fusiform gyrus. We did not detect any significant sex differences or sex‐by‐age interactions, suggesting that the size of the fusiform gyrus is similar in male and female brains and that age‐related atrophy follows a similar trajectory in both men and women.

中文翻译：

衰老对健康老年人梭状回亚区的影响

众所周知，梭状回的大小随着年龄的增长而减小。然而，报告的结果不一致，现有的研究在检查的队列和/或应用的方法方面存在差异。在这里，我们通过将基于成像的强度信息与微观定义的细胞结构概率相结合，分析了梭状回四个不同子区域中与年龄相关的联系。除了年龄影响之外，我们还对涵盖广泛年龄范围（42-97 岁）的 468 名健康受试者（272 名女性/196 名男性）的相对较大样本调查了性别影响以及年龄与性别之间的相互作用。我们观察到年龄与梭状回的所有四个子区域之间存在显着的负相关，表明体积随着时间的推移而减少，尽管具有特定于子区域的轨迹。此外，我们观察到一些子区域与年龄的显着负二次关联，表明随着时间的推移体积损失加速。这些发现可以作为未来横断面和纵向研究的参考框架，不仅适用于正常样本，还可能适用于呈现梭状回异常萎缩的临床状况。我们没有检测到任何显着的性别差异或不同年龄的相互作用，这表明男性和女性大脑中梭状回的大小相似，并且男性和女性的年龄相关萎缩遵循相似的轨迹。不仅适用于正常样本，还可能适用于呈现梭状回异常萎缩的临床状况。我们没有检测到任何显着的性别差异或不同年龄的相互作用，这表明男性和女性大脑中梭状回的大小相似，并且男性和女性的年龄相关萎缩遵循相似的轨迹。不仅适用于正常样本，还可能适用于呈现梭状回异常萎缩的临床状况。我们没有检测到任何显着的性别差异或不同年龄的相互作用，这表明男性和女性大脑中梭状回的大小相似，并且男性和女性的年龄相关萎缩遵循相似的轨迹。

更新日期：2020-03-08

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