The striatal dopamine system has long been studied in the context of reward learning, motivation, and movement. Given the prominent role dopamine plays in a variety of adaptive behavioral states, as well as diseases like addiction, it is essential to understand the full complexity of dopamine neurons and the striatal systems they target. A growing number of studies are uncovering details of the heterogeneity in dopamine neuron subpopulations. Here, we review that work to synthesize current understanding of dopamine system heterogeneity across three levels, anatomical organization, functions in behavior, and modes of action, wherein we focus on signaling profiles and local mechanisms for modulation of dopamine release. Together, these studies reveal new and emerging dimensions of the striatal dopamine system, informing its contribution to dynamic motivational and decision-making processes.

中文翻译：

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纹状体多巴胺回路的异质性：动态奖励寻求中的形式和功能。


纹状体多巴胺系统长期以来一直在奖励学习、动机和运动的背景下进行研究。鉴于多巴胺在各种适应性行为状态以及成瘾等疾病中发挥着重要作用，因此有必要了解多巴胺神经元及其针对的纹状体系统的全部复杂性。越来越多的研究正在揭示多巴胺神经元亚群异质性的细节。在这里，我们回顾了目前对多巴胺系统异质性的理解，包括解剖组织、行为功能和作用模式三个层面，其中我们重点关注信号传导谱和调节多巴胺释放的局部机制。这些研究共同揭示了纹状体多巴胺系统的新维度，揭示了其对动态动机和决策过程的贡献。