Heterogeneity in major depressive disorder (MDD) is well recognized but not well understood. Core depressive features are reward and emotional symptoms, which reflect dysfunctions in the positive valence (PV) and negative valence (NV) systems, respectively. This study assessed whether PV and NV systems (based on selected symptoms) were associated with different clinical features, antidepressant response, and levels of immunomarkers in adults with MDD.

中文翻译：

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重度抑郁症的正价和负价系统具有不同的临床特征、对抗抑郁药的反应以及与免疫标志物的关系。

重度抑郁症 (MDD) 的异质性已得到广泛认可，但尚未得到充分理解。核心抑郁特征是奖励和情绪症状，分别反映了正价（PV）和负价（NV）系统的功能障碍。这项研究评估了 PV 和 NV 系统（基于选定的症状）是否与 MDD 成人的不同临床特征、抗抑郁反应和免疫标志物水平相关。