Extraembryonic endoderm (XEN) cells are isolated from primitive endoderm (PrE) of blastocysts. Just like PrE, XEN cells have the ability to differentiate into parietal endoderm (PE) and visceral endoderm (VE), and therefore, they are useful tools for studying mechanisms of PrE cells development and differentiation. Pig is an ideal model for studying human cardiovascular and metabolic diseases and a potential organ source for allotransplantation, while no XEN cell has been obtained from porcine embryos.

中文翻译：

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从囊胚中衍生猪胚胎外内胚层样细胞

胚外内胚层 (XEN) 细胞是从囊胚的原始内胚层 (PrE) 中分离出来的。与PrE一样，XEN细胞具有分化为壁内胚层（PE）和内脏内胚层（VE）的能力，因此，它们是研究PrE细胞发育和分化机制的有用工具。猪是研究人类心血管和代谢疾病的理想模型，也是同种异体移植的潜在器官来源，但目前尚未从猪胚胎中获得XEN细胞。