Oestrogen‐activated autophagy has a negative effect on the anti‐osteoclastogenic function of oestrogen,Cell Proliferation

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Oestrogen‐activated autophagy has a negative effect on the anti‐osteoclastogenic function of oestrogen
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-03-11 , DOI: 10.1111/cpr.12789
Liang Cheng ₁ , Yunrong Zhu ₂ , Dianshan Ke ₁ , Denghui Xie ₁

Affiliation

Oestrogen is known to inhibit osteoclastogenesis, and numerous studies have identified it as an autophagic activator. To date, the role of oestrogen in the autophagy of osteoclast precursors (OCPs) during osteoclastogenesis remains unclear. This study aimed to determine the effect of autophagy regulated by the biologically active form of oestrogen (17β‐estradiol) on osteoclastogenesis.

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