Cardiac Ca2+ signalling plays an essential role in regulating excitation‐contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca2+ signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL‐1 cardiomyocytes subjected to rotation‐simulated microgravity and 4G hypergravity.

中文翻译：

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模拟微重力和超重力诱导心肌细胞钙信号的改变

心脏 Ca2+ 信号传导在调节兴奋-收缩耦合和心脏重塑中起重要作用。然而，心肌细胞对模拟微重力和超重力的反应以及对 Ca2+ 信号的影响仍然未知。在这里，我们阐明了 HL-1 心肌细胞在旋转模拟微重力和 4G 超重力作用下增殖和重塑的机制。