Postflight orthostatic intolerance has been regarded as a major adverse effect after microgravity exposure, in which cerebrovascular adaptation plays a critical role. Our previous finding suggested that dedifferentiation of vascular smooth muscle cells (VSMCs) might be one of the key contributors to cerebrovascular adaptation under simulated microgravity. This study was aimed to confirm this concept and elucidate the underlying mechanisms.

中文翻译：

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miR-137及其靶标T型CaV 3.1通道通过调节钙调神经磷酸酶/NFAT通路调节模拟微重力大鼠脑血管平滑肌细胞的去分化和增殖

飞行后直立不耐受被认为是微重力暴露后的主要不良反应，其中脑血管适应起着关键作用。我们之前的发现表明，血管平滑肌细胞 (VSMCs) 的去分化可能是模拟微重力下脑血管适应的关键因素之一。本研究旨在证实这一概念并阐明其潜在机制。