Central nervous system (CNS) maintains a high level of metabolism, which leads to the generation of large amounts of free radicals, and it is also one of the most vulnerable organs to oxidative stress. Emerging evidences have shown that, as the key homeostatic cells in CNS, astrocytes are deeply involved in multiple aspects of CNS function including oxidative stress regulation. Besides, the redox level in CNS can in turn affect astrocytes in morphology and function. The complex and multiple roles of astrocytes indicate that their correct performance is crucial for the normal functioning of the CNS, and its dysfunction may result in the occurrence and progression of various neurological disorders. To date, the influence of astrocytes in CNS oxidative stress is rarely reviewed. Therefore, in this review we sum up the roles of astrocytes in redox regulation and the corresponding mechanisms under both normal and different pathological conditions.

中文翻译：

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星形胶质细胞在中枢神经系统氧化应激中的作用：喜忧参半

中枢神经系统（CNS）维持高水平的新陈代谢，导致大量自由基的产生，也是最容易受到氧化应激影响的器官之一。新出现的证据表明，作为中枢神经系统关键的稳态细胞，星形胶质细胞深入参与中枢神经系统功能的多个方面，包括氧化应激调节。此外，CNS 中的氧化还原水平反过来会影响星形胶质细胞的形态和功能。星形胶质细胞的复杂和多重作用表明它们的正确表现对中枢神经系统的正常功能至关重要，其功能障碍可能导致各种神经系统疾病的发生和发展。迄今为止，星形胶质细胞在 CNS 氧化应激中的影响很少被审查。所以，