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RNF8 promotes efficient DSB repair by inhibiting the pro‐apoptotic activity of p53 through regulating the function of Tip60
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-03-01 , DOI: 10.1111/cpr.12780
Hongyu Chen 1 , Jin Shan 2 , Jialing Liu 1 , Yunpeng Feng 1 , Yueshuang Ke 1 , Wenjing Qi 3 , Wenguang Liu 1 , Xianlu Zeng 1
Affiliation  

RING finger protein 8 (RNF8) is an E3 ligase that plays an essential role in DSB repair. p53 is a well‐established tumour suppressor and cellular gatekeeper of genome stability. This study aimed at investigating the functional correlations between RNF8 and p53 in DSB damage repair.

中文翻译:

RNF8通过调节Tip60的功能抑制p53的促凋亡活性促进DSB的有效修复

无名指蛋白 8 (RNF8) 是一种 E3 连接酶,在 DSB 修复中起重要作用。p53 是一种成熟的肿瘤抑制因子和基因组稳定性的细胞守门人。本研究旨在研究 RNF8 和 p53 在 DSB 损伤修复中的功能相关性。
更新日期:2020-03-01
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