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A20 inhibits osteoclastogenesis via TRAF6‐dependent autophagy in human periodontal ligament cells under hypoxia
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-03-01 , DOI: 10.1111/cpr.12778
Ke Yan 1 , Chengyu Wu 1 , Yu Ye 1, 2 , Lu Li 1, 2 , Xiaoqian Wang 1, 2 , Wei He 3 , Shuangshuang Ren 1, 2 , Yan Xu 1, 2
Affiliation  

A20 exerts an anti‐osteoclastogenic effect through the inhibition of NF‐κB signalling in periodontitis. It also regulates autophagy via ubiquitin modification. This study was aimed at exploring the relationship between A20 and autophagy in anti‐osteoclastogenesis in human periodontal ligament cells (hPDLCs) under hypoxia.

中文翻译:

A20在缺氧条件下通过TRAF6依赖性自噬抑制人牙周膜细胞中的破骨细胞生成

A20 通过抑制牙周炎中的 NF-κB 信号传导发挥抗破骨细胞作用。它还通过泛素修饰调节自噬。本研究旨在探讨低氧条件下人牙周膜细胞(hPDLCs)抗破骨细胞生成中A20与自噬的关系。
更新日期:2020-03-01
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