A20 inhibits osteoclastogenesis via TRAF6‐dependent autophagy in human periodontal ligament cells under hypoxia,Cell Proliferation

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A20 inhibits osteoclastogenesis via TRAF6‐dependent autophagy in human periodontal ligament cells under hypoxia
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-03-01 , DOI: 10.1111/cpr.12778
Ke Yan ₁ , Chengyu Wu ₁ , Yu Ye _{1,

2} , Lu Li _{1,

2} , Xiaoqian Wang _{1,

2} , Wei He ₃ , Shuangshuang Ren _{1,

2} , Yan Xu _{1,

2}

Affiliation

A20 exerts an anti‐osteoclastogenic effect through the inhibition of NF‐κB signalling in periodontitis. It also regulates autophagy via ubiquitin modification. This study was aimed at exploring the relationship between A20 and autophagy in anti‐osteoclastogenesis in human periodontal ligament cells (hPDLCs) under hypoxia.

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