The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance,Cell Proliferation

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The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-03-01 , DOI: 10.1111/cpr.12779
Liang Kang _{1,

2} , Shiwei Liu _{1,

2} , Jingchao Li _{1,

2,

3} , Yueyang Tian _{1,

2} , Yuan Xue _{1,

2} , Xiaozhi Liu ₄

Affiliation

Mitochondrial dysfunction, oxidative stress and nucleus pulposus (NP) cell apoptosis are important contributors to the development and pathogenesis of intervertebral disc degeneration (IDD). Here, we comprehensively evaluated the effects of mitochondrial dynamics, mitophagic flux and Nrf2 signalling on the mitochondrial quality control, ROS production and NP cell survival in in vitro and ex vivo compression models of IDD and explored the effects of the mitochondria‐targeted anti‐oxidant MitoQ and its mechanism.

中文翻译：

线粒体靶向抗氧化剂 MitoQ 通过改善线粒体功能障碍和氧化还原失衡来防止椎间盘退变

线粒体功能障碍、氧化应激和髓核 (NP) 细胞凋亡是导致椎间盘退变 (IDD) 发生和发病的重要因素。在这里，我们综合评估了线粒体动力学、线粒体通量和 Nrf2 信号对 IDD 体外和离体压缩模型中线粒体质量控制、ROS 产生和 NP 细胞存活的影响，并探讨了线粒体靶向抗氧化剂的作用MitoQ 及其机制。

更新日期：2020-03-01

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