Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer/testis antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and immunotherapy response in human cancers. PRAME is highly expressed in different types of cancers and is involved in cell proliferation, apoptosis, differentiation and metastasis as well as the outcomes of patients with cancer. In this review article, we discuss the potential roles and physiological functions of PRAME in various types of cancers. Moreover, this review highlights immunotherapeutic strategies that target PRAME in human malignancies. Therefore, the modulation of PRAME might be useful for the treatment of patients with cancer.

中文翻译：

---

癌症睾丸抗原PRAME在人类癌症的肿瘤发生和免疫治疗中的作用

黑色素瘤中优先表达的抗原 (PRAME) 属于癌症/睾丸抗原 (CTA) 基因家族，在人类癌症的多个细胞过程和免疫治疗反应中起着关键作用。PRAME在不同类型的癌症中高表达，参与细胞增殖、凋亡、分化和转移以及癌症患者的预后。在这篇综述文章中，我们讨论了 PRAME 在各种癌症中的潜在作用和生理功能。此外，本综述强调了针对人类恶性肿瘤中 PRAME 的免疫治疗策略。因此，PRAME 的调节可能有助于治疗癌症患者。