Scoliosis, a complex three‐dimensional deformity of the spine with the Cobb angle (a measure of the spinal lateral curvature) >10 degree, encompasses a spectrum of pathologies, including congenital, idiopathic, syndromic and neuromuscular aetiologies. The pathogenesis is multifactorial involving both environmental and genetic factors but the exact cellular and molecular mechanisms of disease development remain largely unknown. Emerging evidence showed that non‐coding RNAs (ncRNAs), namely microRNAs, long ncRNAs and circular RNAs, are deregulated in many orthopaedic diseases, including scoliosis. Importantly, these deregulated ncRNAs functionally participate in the initiation and progression of scoliosis. Here, we review recent progress in ncRNA research on scoliosis.

中文翻译：

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非编码RNA在脊柱侧弯中的新作用

脊柱侧弯是一种复杂的脊柱三维畸形，Cobb 角（脊柱侧弯的度量）> 10 度，包括一系列病理，包括先天性、特发性、综合征和神经肌肉病因。发病机制是多因素的，涉及环境和遗传因素，但疾病发展的确切细胞和分子机制在很大程度上仍然未知。新出现的证据表明，非编码 RNA (ncRNA)，即 microRNA、长 ncRNA 和环状 RNA，在许多骨科疾病（包括脊柱侧弯）中失调。重要的是，这些失调的 ncRNA 在功能上参与了脊柱侧弯的发生和进展。在这里，我们回顾了脊柱侧弯 ncRNA 研究的最新进展。