Mixed lineage leukaemia protein‐1 (MLL1) mediates histone 3 lysine 4 (H3K4) trimethylation (me3) and plays vital roles during early embryonic development and hematopoiesis. In our previous study, we found its expression was positively correlated with embryonic myogenic ability in pigs, indicating its potential roles in mammalian muscle development. The present work aimed to explore the roles and regulation mechanisms of MLL1 in myogenesis.

中文翻译：

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MLL1通过表观遗传调节Myf5促进肌生成

混合谱系白血病蛋白 1 (MLL1) 介导组蛋白 3 赖氨酸 4 (H3K4) 三甲基化 (me3)，并在早期胚胎发育和造血过程中发挥重要作用。在我们之前的研究中，我们发现其表达与猪的胚胎生肌能力呈正相关，表明其在哺乳动物肌肉发育中的潜在作用。目前的工作旨在探索 MLL1 在肌生成中的作用和调节机制。