The jumonji domain‐containing protein 6 (JMJD6) is a Fe(II)‐ and 2‐oxoglutarate (2OG)‐dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of histone and non‐histone peptides. Recently, the intrinsic tyrosine kinase activity of JMJD6 has also been reported. The JMJD6 has been implicated in embryonic development, cellular proliferation and migration, self‐tolerance induction in the thymus, and adipocyte differentiation. Not surprisingly, abnormal expression of JMJD6 may contribute to the development of many diseases, such as neuropathic pain, foot‐and‐mouth disease, gestational diabetes mellitus, hepatitis C and various types of cancer. In the present review, we summarized the structure and functions of JMJD6, with particular emphasis on the role of JMJD6 in cancer progression.

中文翻译：

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含 Jumonji 结构域的蛋白 6 蛋白及其在癌症中的作用

含有 jumonji 结构域的蛋白 6 (JMJD6) 是一种 Fe(II) 和 2-酮戊二酸 (2OG) 依赖性加氧酶，可催化组蛋白和非组蛋白肽的赖氨酸羟基化和精氨酸去甲基化。最近，还报道了 JMJD6 的内在酪氨酸激酶活性。JMJD6 与胚胎发育、细胞增殖和迁移、胸腺自我耐受诱导和脂肪细胞分化有关。毫不奇怪，JMJD6 的异常表达可能导致许多疾病的发展，如神经性疼痛、口蹄疫、妊娠糖尿病、丙型肝炎和各种类型的癌症。在本综述中，我们总结了 JMJD6 的结构和功能，特别强调了 JMJD6 在癌症进展中的作用。