Bioengineered microenvironment to culture early embryos,Cell Proliferation

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Bioengineered microenvironment to culture early embryos
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-01-09 , DOI: 10.1111/cpr.12754
Zhen Gu _{1,

2} , Jia Guo ₃ , Hongmei Wang ₄ , Yongqiang Wen ₁ , Qi Gu _{3,

5}

Affiliation

The abnormalities of early post‐implantation embryos can lead to early pregnancy loss and many other syndromes. However, it is hard to study embryos after implantation due to the limited accessibility. The success of embryo culture in vitro can avoid the challenges of embryonic development in vivo and provide a powerful research platform for research in developmental biology. The biophysical and chemical cues of the microenvironments impart significant spatiotemporal effects on embryonic development. Here, we summarize the main strategies which enable researchers to grow embryos outside of the body while overcoming the implantation barrier, highlight the roles of engineered microenvironments in regulating early embryonic development, and finally discuss the future challenges and new insights of early embryo culture.

中文翻译：

用于培养早期胚胎的生物工程微环境

早期植入后胚胎的异常可导致早期妊娠丢失和许多其他综合征。然而，由于可及性有限，很难研究植入后的胚胎。体外胚胎培养的成功避免了体内胚胎发育的挑战，为发育生物学的研究提供了一个强大的研究平台。微环境的生物物理和化学线索对胚胎发育具有显着的时空影响。在这里，我们总结了使研究人员能够在体外培养胚胎同时克服着床障碍的主要策略，强调工程微环境在调节早期胚胎发育中的作用，最后讨论早期胚胎培养的未来挑战和新见解。

更新日期：2020-01-09

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