Sitting in the Driver's Seat: Manipulation of Mammalian Cell Rab GTPase functions by Apicomplexan Parasites,Biology of the Cell

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Sitting in the Driver's Seat: Manipulation of Mammalian Cell Rab GTPase functions by Apicomplexan Parasites
Biology of the Cell ( IF 2.4 ) Pub Date : 2020-04-06 , DOI: 10.1111/boc.201900107
Isabelle Coppens ₁ , Julia D Romano ₁

Affiliation

Many intracellular microbial pathogens subvert, disrupt or otherwise modulate host membrane trafficking pathways to establish a successful infection. Among them, bacteria that are trapped in a phagosome during mammalian cell invasion, disengage the programmed degradation process by altering the identity of their replicative niche through the exclusion or recruitment of specific Rab GTPases to their vacuole. Many viruses co‐opt essential cellular trafficking pathways to perform key steps in their lifecycles. Among protozoan parasites, Apicomplexa are obligate intracellular microbes that invade mammalian cells by creating a unique, nonfusogenic membrane‐bound compartment that protects the parasites straightaway from lysosomal degradation. Recent compelling evidence demonstrates that apicomplexan parasites are master manipulators of mammalian Rab GTPase proteins, and benefit or antagonise Rab functions for development within host cells. This review covers the exploitation of mammalian Rab proteins and vesicles by Apicomplexa, focusing on Toxoplasma, Neospora, Plasmodium and Theileria parasites.

中文翻译：

坐在驾驶座上：Apicomplexan 寄生虫对哺乳动物细胞 Rab GTPase 功能的操纵

许多细胞内微生物病原体破坏、破坏或以其他方式调节宿主膜运输途径以建立成功的感染。其中，在哺乳动物细胞入侵期间被困在吞噬体中的细菌，通过将特定的 Rab GTPases 排除或募集到其液泡来改变其复制生态位的身份，从而脱离程序化的降解过程。许多病毒选择必要的细胞运输途径来执行其生命周期中的关键步骤。在原生动物寄生虫中，Apicomplexa 是专性细胞内微生物，通过创建独特的非融合膜结合隔室来侵入哺乳动物细胞，保护寄生虫免于溶酶体降解。最近令人信服的证据表明，顶端复合体寄生虫是哺乳动物 Rab GTPase 蛋白的主要操纵者，并且有利于或拮抗 Rab 功能以在宿主细胞内发育。这篇综述涵盖了 Apicomplexa 对哺乳动物 Rab 蛋白和囊泡的开发，重点是弓形虫、新孢子虫、疟原虫和泰勒虫寄生虫。

更新日期：2020-04-06

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