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Subtelomeres as Specialized Chromatin Domains
BioEssays ( IF 3.2 ) Pub Date : 2020-03-17 , DOI: 10.1002/bies.201900205 Antoine Hocher 1, 2 , Angela Taddei 3, 4
BioEssays ( IF 3.2 ) Pub Date : 2020-03-17 , DOI: 10.1002/bies.201900205 Antoine Hocher 1, 2 , Angela Taddei 3, 4
Affiliation
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Specificities associated with chromosomal linearity are not restricted to telomeres. Here, recent results obtained on fission and budding yeast are summarized and an attempt is made to define subtelomeres using chromatin features extending beyond the heterochromatin emanating from telomeres. Subtelomeres, the chromosome domains adjacent to telomeres, differ from the rest of the genome by their gene content, rapid evolution, and chromatin features that together contribute to organism adaptation. However, current definitions of subtelomeres are generally based on synteny and are largely gene‐centered. Taking into consideration both the peculiar gene content and dynamics as well as the chromatin properties of those domains, it is discussed how chromatin features can contribute to subtelomeric properties and functions, and play a pivotal role in the emergence of subtelomeres.
中文翻译：
亚端粒作为专门的染色质域
与染色体线性相关的特异性不限于端粒。在这里，总结了最近在裂变和出芽酵母上获得的结果，并尝试使用超出端粒发出的异染色质的染色质特征来定义亚端粒。亚端粒是与端粒相邻的染色体结构域，其基因含量、快速进化和染色质特征与基因组的其余部分不同，这些共同有助于生物体适应。然而，目前亚端粒的定义通常基于同线性并且主要以基因为中心。考虑到这些域的特殊基因内容和动态以及染色质特性，讨论了染色质特征如何有助于亚端粒特性和功能，
更新日期：2020-04-22
中文翻译：
亚端粒作为专门的染色质域
与染色体线性相关的特异性不限于端粒。在这里，总结了最近在裂变和出芽酵母上获得的结果，并尝试使用超出端粒发出的异染色质的染色质特征来定义亚端粒。亚端粒是与端粒相邻的染色体结构域，其基因含量、快速进化和染色质特征与基因组的其余部分不同，这些共同有助于生物体适应。然而，目前亚端粒的定义通常基于同线性并且主要以基因为中心。考虑到这些域的特殊基因内容和动态以及染色质特性，讨论了染色质特征如何有助于亚端粒特性和功能，
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