Volumetric Raman chemical imaging of drug delivery systems,Journal of Raman Spectroscopy

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Volumetric Raman chemical imaging of drug delivery systems
Journal of Raman Spectroscopy ( IF 2.4 ) Pub Date : 2020-03-08 , DOI: 10.1002/jrs.5869
Roman Slipets ₁ , Oleksii Ilchenko ₁ , Chiara Mazzoni ₁ , Fabio Tentor ₁ , Line Hagner Nielsen ₁ , Anja Boisen ₁

Affiliation

The ability to image drug distribution inside a several hundred micron thick polymer matrix, encapsulated by a protective coating, would greatly contribute to the understanding of the performance and shortcomings of drug delivery devices. Here, we present an experimental framework for deep volumetric Raman imaging (dVRI), where common challenges such as low Raman cross section, fluorescence, and low transparency of samples are overcome. We apply dVRI to a selection of drug delivery forms, tablets with thin protective coatings and drug‐loaded microdevices. We demonstrate three‐dimensional visualization of the different drug/polymeric materials, constituting a drug delivery device, with imaging depth of 225 μm.

中文翻译：

药物输送系统的体积拉曼化学成像

通过保护性涂层封装的数百微米厚的聚合物基质内部的药物分布成像的能力，将极大地有助于理解药物输送装置的性能和缺点。在这里，我们介绍了用于深体积拉曼成像（dVRI）的实验框架，克服了诸如低拉曼横截面，荧光和样品透明度低等常见挑战。我们将dVRI应用于各种药物递送形式，具有薄保护膜的片剂和载有药物的微型设备。我们演示了构成药物输送装置的不同药物/聚合物材料的三维可视化，成像深度为225μm。

更新日期：2020-03-08

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