Strontium‐based medications, such as strontium ranelate, have been suggested to have therapeutic effects in patients with osteoporosis. Strontium salts available off‐shelf in stores across North America are assumed to provide similar effects as strontium ranelate and thus should lead to similar distributions of elemental strontium incorporated in bone. The objective of this study was to compare the spatial distribution of strontium in animal bones following the administration of strontium ranelate and strontium citrate. Seventeen‐week‐old Sprague–Dawley rats were split into three groups over 10 weeks and given 625 mg/kg/day of strontium ranelate and 676 mg/kg/day of strontium citrate; the control group received no additional supplementary strontium. The humeri were collected from all animals, and strontium distribution was mapped using 2D micro‐XRF and 3D dual energy K‐edge subtraction (KES) imaging. 2D and 3D elemental mapping methods demonstrated that strontium delivered during treatment by both salts had the same spatial distribution. 3D elemental strontium maps of treated animal bones showed that strontium was largely observed in the trabecular regions under the epiphyseal (growth) plate. The thickness of the strontium layers in both the strontium ranelate and strontium citrate sample was not significantly different (p = .9201). 2D micro‐XRF and 3D dual‐energy KES images effectively elucidated the spatial distribution of elemental strontium in calcified tissue. These methods provide a novel approach to evaluating the potential efficacy of strontium supplements in the treatment of osteoporosis.

中文翻译：

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使用2D micro-XRF和3D双能K边减影同步加速器成像技术测定雷奈酸锶和柠檬酸锶处理的大鼠骨骼中的锶元素分布

已建议基于锶的药物，如雷奈酸锶，对骨质疏松症患者具有治疗作用。北美各地商店中现成的锶盐被认为具有与雷奈酸锶相似的作用，因此会导致掺入骨骼中的元素锶分布相似。这项研究的目的是比较施用雷奈酸锶和柠檬酸锶后动物骨骼中锶的空间分布。在10周内将17周龄的Sprague-Dawley大鼠分为三组，分别给予雷奈酸锶625 mg / kg /天和柠檬酸锶676 mg / kg /天。对照组没有额外的补充锶。肱骨取自所有动物，使用2D micro-XRF和3D双能量K边缘减影（KES）成像绘制锶分布图。2D和3D元素映射方法表明，两种盐在处理过程中输送的锶具有相同的空间分布。处理过的动物骨骼的3D元素锶图显示，在骨phy（生长）板下方的小梁区域中大量观察到了锶。雷奈酸锶和柠檬酸锶样品中锶层的厚度没有显着差异（处理过的动物骨骼的3D元素锶图显示，在骨phy（生长）板下方的小梁区域中大量观察到了锶。雷奈酸锶和柠檬酸锶样品中锶层的厚度没有显着差异（处理过的动物骨骼的3D元素锶图显示，在骨phy（生长）板下方的小梁区域中大量观察到了锶。雷奈酸锶和柠檬酸锶样品中锶层的厚度没有显着差异（p = .9201）。2D micro-XRF和3D双能KES图像可有效阐明钙化组织中元素锶的空间分布。这些方法提供了一种新颖的方法来评估锶补充剂在骨质疏松症治疗中的潜在功效。