Silymarin attenuated nonalcoholic fatty liver disease through the regulation of endoplasmic reticulum stress proteins GRP78 and XBP-1 in mice.,Journal of Food Biochemistry

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Silymarin attenuated nonalcoholic fatty liver disease through the regulation of endoplasmic reticulum stress proteins GRP78 and XBP-1 in mice.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-03-18 , DOI: 10.1111/jfbc.13194
Erhan Sahin ₁ , Ridvan Bagci ₁ , Nuriye Ezgi Bektur Aykanat ₁ , Sedat Kacar ₁ , Varol Sahinturk ₁

Affiliation

Nonalcoholic fatty liver disease (NAFLD) is an important health problem. The prevalence of NAFLD is increasing, especially in the Western countries. Although there are several intracellular pathways in NAFLD, endoplasmic reticulum (ER) stress has recently gained importance. Silymarin is an important liver‐protective biological molecule. In light of this information, we investigated mice for the effect of silymarin on ER stress in the NAFLD model. In our study, the mice were randomly divided into six groups: Control, silymarin 100 and 200 mg/kg sham, fructose‐induced NAFLD, and NAFLD + silymarin groups. After the last administrations, liver and blood samples were taken and hematoxylin‐eosin, as well as Oil red O staining, were performed. As a result, the body and liver weights, lipid profile, AST, ALT, and glucose levels, along with the ER stress markers, increased in the NAFLD‐only group. Silymarin treatments reversed most of these changes. Particularly, 200 mg/kg silymarin was more effective.

中文翻译：

水飞蓟素通过调节小鼠内质网应激蛋白GRP78和XBP-1减轻非酒精性脂肪肝疾病。

非酒精性脂肪肝疾病（NAFLD）是重要的健康问题。NAFLD的患病率正在上升，尤其是在西方国家。尽管NAFLD中存在多种细胞内途径，但是内质网（ER）应激最近变得越来越重要。水飞蓟素是重要的肝脏保护生物分子。根据这些信息，我们在NAFLD模型中研究了水飞蓟素对内质网应激的影响的小鼠。在我们的研究中，小鼠随机分为六组：对照组，水飞蓟素100和200 mg / kg假手术，果糖诱导的NAFLD和NAFLD +水飞蓟素组。最后一次给药后，采集肝脏和血液样本，并进行苏木精-曙红和油红O染色。结果，人体和肝脏的重量，脂质状况，AST，ALT和葡萄糖水平，仅NAFLD组中的ER应力标记与ER标记一起增加。水飞蓟素治疗逆转了大多数这些变化。特别地，200 mg / kg水飞蓟素更有效。

更新日期：2020-03-18

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