Nutraceuticals for prevention of atherosclerosis: Targeting monocyte infiltration to the vascular endothelium.,Journal of Food Biochemistry

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Nutraceuticals for prevention of atherosclerosis: Targeting monocyte infiltration to the vascular endothelium.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-03-18 , DOI: 10.1111/jfbc.13200
Min Jeong Kim ₁ , Sung Keun Jung _{1,

2}

Affiliation

Cardiovascular disease (CVD) is the leading cause of death, globally, and is a serious problem in developing countries. Preventing atherosclerosis is key to reducing the risk of developing CVD. Similar to carcinogenesis, atherogenesis can be divided into four stages: initiation, promotion, progression, and acute events. The current study focuses on the promotion stage, which is characterized by circular monocyte penetration into vascular endothelial cells, monocyte differentiation into macrophages, and the formation of foam cells. This early stage of atherogenesis is a major target for nutraceuticals. We discuss nutraceuticals that can potentially inhibit monocyte adhesion to the vascular endothelium, thereby preventing the promotional stage of atherosclerosis. The mechanisms through which these nutraceuticals prevent monocyte adhesion are classified according to the following targets: NF‐κB, ROS, MAPKs, and AP‐1. Additionally, we discuss promising targets for nutraceuticals that can regulate monocyte adhesion to the endothelium.

更新日期：2020-03-18

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