Cancer is the major cause of death and many factors that lead to its occurrences, such as environmental pollution and pesticides and other factors. Ehrlich carcinoma development depends on many things associated with the environment, nutrition, personal habits, and family history. The present study aimed to evaluate the potential protective effects of vitamin B17 (VB17) against Ehrlich ascites carcinoma (EAC) that induced kidney toxicity in female mice. The mice were divided into five groups (first group, control group; second group, VB17 group; third group, EAC group; fourth group, pretreated EAC with VB17; fifth group, cotreated EAC with VB17). Results showed the VB17 in pretreated (G4) and cotreated (G5) groups lead to an improvement in DNA damage and cytological examination, in addition significantly (P < .05) increase in Na+, red blood cell, hemoglobin, hematocrit value, mean corpuscular hemoglobin (MCH), and MCH concentration, whereas significantly (P < .05) decrease in urea, creatinine, K+, platelets, and white blood cells while insignificant (P < .05) changes in mean corpuscular volume when compared to the EAC group. Many histopathological changes were observed in kidney sections in EAC as marked damage and degenerated, glomerular atrophy, the Malpighian corpuscles that lost their characteristic configuration. On the other hand, a moderate improvement and arrangement in the kidney histological structure in pretreated VB17 + EAC, while a mild enhancement and arrangement of the kidney structure in cotreated EAC + VB17. In addition, depletion in renal P53 and PCNA protein expression compared with the EAC group. It could be concluded that VB17 has a potential renal protective effect against EAC cells induced kidney injury.

中文翻译：

---

维生素B17对肾脏抗艾氏腹水癌小鼠肾毒性的改善作用

癌症是导致其发生的主要原因，环境污染和农药等因素是导致其发生的主要原因。Ehrlich 癌的发展取决于许多与环境、营养、个人习惯和家族史相关的因素。本研究旨在评估维生素 B17 (VB17) 对诱导雌性小鼠肾毒性的艾氏腹水癌 (EAC) 的潜在保护作用。将小鼠分为五组（第一组，对照组；第二组，VB17组；第三组，EAC组；第四组，用VB17预处理EAC；第五组，用VB17共同处理EAC）。结果显示，预处理 (G4) 和共同处理 (G5) 组中的 VB17 导致 DNA 损伤和细胞学检查的改善，此外 Na+ 显着增加 (P < .05)，红细胞、血红蛋白、血细胞比容值、平均红细胞血红蛋白 (MCH) 和 MCH 浓度，而尿素、肌酐、K+、血小板和白细胞显着降低 (P < .05)，但不显着 (P < .05)与 EAC 组相比，平均红细胞体积的变化。在 EAC 的肾脏切片中观察到许多组织病理学变化，表现为显着的损伤和退化的肾小球萎缩，马氏小体失去其特征配置。另一方面，预处理的 VB17 + EAC 中肾脏组织结构的适度改善和排列，而联合处理的 EAC + VB17 中肾脏结构的轻度增强和排列。此外，与 EAC 组相比，肾 P53 和 PCNA 蛋白表达的消耗。