A Quantitative Multi‐Criteria Solvent Selection Method for Extraction Processes: Case Study—Downstream Purification of Sucrose‐Based Surfactants,Journal of Surfactants and Detergents

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A Quantitative Multi‐Criteria Solvent Selection Method for Extraction Processes: Case Study—Downstream Purification of Sucrose‐Based Surfactants
Journal of Surfactants and Detergents ( IF 1.6 ) Pub Date : 2020-02-11 , DOI: 10.1002/jsde.12397
Javier E. Chavarrio ₁ , María F. Gutiérrez ₁ , Álvaro Orjuela ₁

Affiliation

This work developed a novel method for the identification and selection of green solvents for extraction processes. The methodology was experimentally validated in the downstream separation of sucrose‐based surfactants obtained from a solvent‐free transesterification of sucrose and methyl palmitate (MP). First, a preliminary solvent screening was carried out taking into account environmental consciousness, extraction effectiveness, and predicted operating costs, combining both theoretical and empirical inputs. Potential solvents were first selected from a green solvents list used at the pharmaceutical industry, and the affinity with reactants was assessed based on the Hansen solubility parameters. Solvent suitability was ranked according to a novel objective function that incorporated the heat of vaporization, normal boiling point, cost, and availability. In the case of study, ethyl acetate was identified as the most promising solvent for MP extraction. This and other solvents were experimentally evaluated to validate the selection method and to assess their extraction performance. According to different effectiveness criteria, ethyl acetate was confirmed as the preferable extraction solvent. Finally, MP extraction from reaction media was optimized, varying temperature, number of stages, and solvent loading. Purified sucrose esters were subjected to bleaching obtaining a product under market specifications.

中文翻译：

萃取过程的定量多标准溶剂选择方法：案例研究—基于蔗糖的表面活性剂的下游纯化

这项工作开发了一种新方法，用于鉴定和选择萃取过程中的绿色溶剂。该方法在从蔗糖和棕榈酸甲酯（MP）的无溶剂酯交换反应中获得的基于蔗糖的表面活性剂的下游分离中进行了实验验证。首先，结合环境和理论输入，结合环境意识，提取效果和预计的运营成本进行了初步溶剂筛选。首先从制药行业使用的绿色溶剂列表中选择潜在的溶剂，然后根据Hansen溶解度参数评估与反应物的亲和力。根据新的目标函数对溶剂的适用性进行了排名，该函数结合了汽化热，正常沸点，成本，和可用性。在研究的情况下，乙酸乙酯被认为是MP提取最有希望的溶剂。对该溶剂和其他溶剂进行了实验评估，以验证选择方法并评估其提取性能。根据不同的有效性标准，确认乙酸乙酯是优选的萃取溶剂。最后，对反应介质中的MP提取进行了优化，改变了温度，阶段数和溶剂用量。对纯化的蔗糖酯进行漂白，得到市场规格的产品。根据不同的有效性标准，确认乙酸乙酯是优选的萃取溶剂。最后，对反应介质中的MP提取进行了优化，改变了温度，阶段数和溶剂用量。对纯化的蔗糖酯进行漂白，得到市场规格的产品。根据不同的有效性标准，确认乙酸乙酯是优选的萃取溶剂。最后，对反应介质中的MP提取进行了优化，改变了温度，段数和溶剂用量。对纯化的蔗糖酯进行漂白，得到市场规格的产品。

更新日期：2020-02-11

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