Owing to their ability to adsorb at interfaces, polysorbates have an important role in pharmaceutical formulations. Because surfactant mixtures can have improved properties, it was hypothesized in this work that introduction of poloxamer 407 to aqueous solutions of polysorbates (polysorbate 60, polysorbate 80 and polysorbate 85) might improve their surface properties. Nonideal behavior of surfactant mixtures at the air/water interface was investigated using Rosen's model and recently introduced method for the determination and quantification of nonideal behavior regarding surface tension reduction and adsorption effectiveness. Although nonideal behavior was noticed in all mixed monolayers, it was shown that the structure of the hydrophobic domain of the polysorbates and the conformation of poloxamer 407 at the interface have strong influence on the nonideality.

中文翻译：

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泊洛沙姆407对聚山梨酯表面活性剂水溶液表面性能的影响

由于其在界面处的吸附能力，聚山梨酯在药物制剂中具有重要作用。因为表面活性剂混合物可以具有改善的性能，所以在这项工作中假设将泊洛沙姆407引入聚山梨酸酯的水溶液（聚山梨酸酯60，聚山梨酸酯80和聚山梨酸酯85）可以改善其表面性能。使用Rosen模型研究了表面活性剂混合物在空气/水界面的非理想行为，最近引入了用于确定和量化有关表面张力降低和吸附效果的非理想行为的方法。尽管在所有混合单层中都注意到了非理想行为，