ABSTRACT

An association between type 2 diabetes mellitus (T2DM) and chronic hepatitis C (CHC) infection have been shown by many studies. The present study investigated the role of vaspin and apelin and their association with biochemical, clinical and histopathological parameters in patients with CHC with and without diabetes in 40 patients (20 with CHC without diabetes and 20 CHC with diabetes) and 20 as controls. Our results showed that apelin increased significantly in CHC patients with diabetes (4.01 ± 1.40 ng/ml) and in CHC patients without diabetes (3.39 ± 1.37 ng/ml)compared to control group (1.84 ± 0.8 ng/ml). Vaspin showed significant decrease in CHC patients without diabetes (0.83 ± 0.20 ng/ml) than control group (1.14 ± 0.56 ng/ml). Vaspin significantly increased in CHC patients with diabetes(1.40 ± 0.31 ng/ml) in comparison with control group. Progressive fibrosis is associated with rise of both apelin and vaspin levels. We conclude that vaspin and apelin could be used as specific predictors for liver fibrosis in CHC patients with and without diabetes. Since serum apelin and vaspin significantly correlated with serum level of liver enzymes in CHC patients, this may emphasize the role of apelin and vaspin in the pathogenesis of this liver disease.

摘要

许多研究表明2型糖尿病（T2DM）与慢性丙型肝炎（CHC）感染之间存在关联。本研究调查了40名患者（20名无糖尿病的CHC和20名糖尿病的CHC）中，患有和不患有糖尿病的CHC患者中vaspin和apelin的作用及其与生化，临床和组织病理学参数的关系。我们的结果显示，与对照组相比，糖尿病的CHC患者（4.01±1.40 ng / ml）和无糖尿病的CHC患者的apelin显着增加（3.39±1.37 ng / ml）。在没有糖尿病的CHC患者中，Vaspin显着降低（0.83±0.20 ng / ml），而对照组（1.14±0.56 ng / ml）降低。与对照组相比，CHC糖尿病患者的Vaspin显着增加（1.40±0.31 ng / ml）。进行性纤维化与apelin和vaspin水平的升高有关。我们得出的结论是，vaspin和apelin可以用作患有和不患有糖尿病的CHC患者肝纤维化的特异性预测指标。由于CHC患者的血清apelin和vaspin与血清肝酶水平显着相关，因此可能强调apelin和vaspin在该肝病发病机理中的作用。