ABSTRACT

Metabolomic profiling of the crude extracts of the three Cycas plants leaves; Cycas armstrongii Miq., Cycas circinalis L., and Cycas revoluta Thunb. showed the presence of diverse secondary metabolites. A detailed phytochemical study of C. armstrongii fractions led to isolation of 15 known components of different classes, but this is the first time to report them for this species. These components were chemically identified as (naringenin, dihydroamentoflavone, 2,3-dihydrohinokiflavone, amentoflavone, 2,3-dihydrobilobetin, isoginkgetin, prunin, naringin, vanillic acid, p-coumaric acid, β-sitosterol, stigmasterol, β-sitosterol glucoside, 3,7,9,11-tetramethyl heptadecanoic acid, and N-(3ʹ-one-5ʹ-methyl)-hexyl-alanine). Moreover, the radioprotective potential of the three Cycas plant species was also investigated, and the ionizing radiation was performed by the exposure of rats whole-body to 8 Gy. The extracts of the three Cycas species were administered at a dose of 200 mg/kg each using an intra-gastric tube. Results indicated that Cycas spp. extracts significantly ameliorated radiation-induced brain and pancreatic damage as well as showing protection against radiation-induced oxidative stress. The results were also proved by histopathological study.

摘要

三种苏铁植物叶片粗提物的代谢组学分析；苏铁，苏铁，苏铁和苏铁。表明存在多种次生代谢产物。对阿姆斯特朗衣原体组分的详细植物化学研究导致分离出15个不同类别的已知组分，但这是首次报道该物种的组分。这些成分在化学上被鉴定为（柚皮苷，二氢甲氢黄酮，2,3-二氢噻吩酮，异黄酮，2,3-二氢胆红素，异oggetgetin，李宁，柚皮苷，香草酸，对香豆酸，β-谷甾醇，豆甾醇，β-谷甾醇葡糖苷，3,7,9,11-四甲基十七烷酸和N-（3ʹ-一个-5ʹ-甲基）-己基丙氨酸）。此外，还研究了三种苏铁属植物的辐射防护潜​​能，并通过将大鼠全身暴露于8 Gy进行电离辐射。使用胃内导管分别以200 mg / kg的剂量施用这3种苏铁属的提取物。结果表明苏铁属。提取物可显着改善辐射诱发的脑和胰腺损伤，并显示出对辐射诱发的氧化应激的保护作用。组织病理学研究也证实了该结果。