Abstract Benzodiazepines (BZD) are frequently prescribed drugs, especially among substance use disorder (SUD) patients. BZD use disorder (BUD) is frequent among SUD patients. However, the number of patients who request help for their BUD is low. Little is known about the characteristics of these patients, as well as comorbidity, compared with those having other SUD. An explorative study with a cross-sectional design was performed. Data were collected in two addiction treatment centres in the Netherlands. The database used included 8122 admissions of patients, and provided data based on the Measurement of the Addictions for Triage and Evaluation (MATE). Baseline characteristic were obtained from registration data systems of the two centres. Baseline characteristics and comorbidity of patients with primary or secondary BUD (n = 207) were compared with those of patients who wanted help for their SUD, BZD excluded (n = 5948), and with patients who used BZD but did not indicate this as a problem (n = 1967). BUD patients proved to be more often female, older, married or widowed/divorced, and slightly higher educated than patients in the comparison category. The severity of dependence and/or misuse was higher. Furthermore, BUD patients more often suffered from symptoms of withdrawal, and from symptoms of depression, anxiety, and stress, as well as from somatic and psychiatric comorbidity. Although the use of benzodiazepines is common in patients with SUD, the number of patients who seek help because of BUD is limited. These patients experience more symptoms in all the above mentioned domains compared to those with other SUD.

中文翻译：

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物质依赖治疗中的苯二氮卓依赖患者：基线特征和合并症

摘要 苯二氮卓类药物 (BZD) 是常用的处方药，尤其是在物质使用障碍 (SUD) 患者中。BZD 使用障碍 (BUD) 在 SUD 患者中很常见。但是，请求 BUD 帮助的患者数量很少。与其他 SUD 患者相比，对这些患者的特征以及合并症知之甚少。进行了具有横断面设计的探索性研究。数据是在荷兰的两个成瘾治疗中心收集的。使用的数据库包括 8122 例入院患者，并提供基于成瘾分类和评估测量 (MATE) 的数据。基线特征是从两个中心的注册数据系统中获得的。将原发性或继发性 BUD 患者（n = 207）的基线特征和合并症与需要帮助治疗 SUD 的患者进行比较，排除 BZD 的患者（n = 5948），以及使用 BZD 但未将其作为问题（n = 1967）。事实证明，BUD 患者更多是女性、年长、已婚或丧偶/离婚，并且受教育程度略高于比较类别的患者。依赖和/或滥用的严重程度更高。此外，BUD 患者更常出现戒断症状、抑郁、焦虑和压力症状，以及躯体和精神共病。虽然苯二氮卓类药物在 SUD 患者中很常见，但因 BUD 寻求帮助的患者数量有限。