Abstract Background: Opioid use disorder is a critical public health concern and the negative effects of opioids on sleep may reinforce addiction. The objective of this pilot study was to incorporate objective and subjective measures to examine if implantable buprenorphine altered patient sleep and quality of life after crossover from daily-dosed sublingual buprenorphine (clinicaltrials.gov ID: NCT02896660). Methods: This pilot study utilized patient self-report and actigraphy to measure the effects of buprenorphine on sleep and quality of life. Patients (n = 15) on sublingual buprenorphine treatment continuously wore an actigraphy device on their wrist for 90 days. Patients’ sleep was monitored for 30 days, after which patients were crossed over to implantable buprenorphine and monitored for 60 days. Patients completed self-assessments at baseline, days 30, 60, and 90. Five randomized patients completed a short qualitative interview at day 90. Results: In actigraphy measures, patient sleep and energy level remained constant following crossover to BI. Both before and after crossover patients perceived their sleep to be worse than that measured by actigraphy; however, quality of life improvements were reported, despite no changes in energy level or sleep efficiency. Conclusions: This is the first time clinically stable buprenorphine patients’ sleep has been evaluated with actigraphy in combination with self-report. Self-report data added valuable context to actigraphy findings. Stabilized dose delivery via implant allowed patients to re-frame their recovery experience, creating positive impacts on psychosocial health and quality of life despite no objective difference in sleep.

中文翻译：

---

丁丙诺啡长效植入物对患者睡眠和生活质量的影响：混合方法试验的结果

摘要背景：阿片类药物使用障碍是一个严重的公共卫生问题，阿片类药物对睡眠的负面影响可能会加剧成瘾。这项试点研究的目的是结合客观和主观的措施来检查植入式丁丙诺啡在与每日给药的舌下丁丙诺啡（clinicaltrials.gov ID：NCT02896660）交叉后是否改变了患者的睡眠和生活质量。方法：这项初步研究利用患者自我报告和活动记录来衡量丁丙诺啡对睡眠和生活质量的影响。接受舌下含丁丙诺啡治疗的患者（n = 15）在手腕上连续佩戴活动记录仪 90 天。患者的睡眠被监测了 30 天，之后患者被转移到可植入的丁丙诺啡并监测了 60 天。患者在基线、第 30、60 和 90 天完成自我评估。五名随机分组的患者在第 90 天完成了一次简短的定性访谈。结果：在活动记录测量中，患者的睡眠和能量水平在交叉到 BI 后保持不变。交叉前后患者都认为他们的睡眠比活动记录仪测量的差；然而，尽管能量水平或睡眠效率没有变化，但据报道生活质量有所改善。结论：这是第一次使用活动记录仪结合自我报告来评估临床稳定的丁丙诺啡患者的睡眠。自我报告数据为活动记录结果增加了有价值的背景。通过植入物稳定的剂量输送使患者能够重新构建他们的康复体验，