ABSTRACT Alongside the obvious health benefits, physical exercise has been shown to have a modest anti-depressant effect for people in the general population. To the authors’ knowledge, there are no current literature reviews or meta-analyses available exploring this effect for people with a traumatic brain injury (TBI). A systematic review of intervention studies utilising physical exercise and mood outcome measures for a TBI population was performed in November 2016. Baseline and outcome data were extracted for the nine studies which met the inclusion criteria. Effect sizes were calculated for the three controlled trials and six uncontrolled trials and entered into the meta-analysis. Consistent with research in non-brain injury populations, the current meta-analysis identified a small to medium effect size of physical exercise on reducing depressive symptoms in people with a TBI. This would support further rigorous trials to provide additional evidence for the efficacy of physical exercise interventions for people with TBI. Limitations of the current meta-analysis and clinical implications are discussed.

中文翻译：

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体育锻炼作为减少创伤性脑损伤后抑郁症状的干预措施的有效性：荟萃分析和系统评价

摘要 除了明显的健康益处外，体育锻炼已被证明对普通人群具有适度的抗抑郁作用。据作者所知，目前没有可用的文献综述或荟萃分析来探索这种对创伤性脑损伤 (TBI) 患者的影响。2016 年 11 月对 TBI 人群利用体育锻炼和情绪结果测量的干预研究进行了系统评价。提取了符合纳入标准的 9 项研究的基线和结果数据。计算了三项对照试验和六项非对照试验的效应量并进入荟萃分析。与非脑损伤人群的研究一致，当前的荟萃分析确定了体育锻炼对减轻 TBI 患者的抑郁症状的影响大小为中小。这将支持进一步严格的试验，为 TBI 患者进行体育锻炼干预的有效性提供额外的证据。讨论了当前荟萃分析的局限性和临床意义。