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Current trends in chemical modifications of magnetic nanoparticles for targeted drug delivery in cancer chemotherapy
Drug Metabolism Reviews ( IF 5.9 ) Pub Date : 2020-02-21
Ahmad Gholami, Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Younes Ghasemi, Wei-Hung Chiang, Najmeh Parvin

Nowadays, magnetic nanoparticles (MNPs) have been rapidly investigated and attracted worldwide attention due to their great potential as mediators of heat for treating hyperthermia and their possibility to deliver drugs at specific locations, which can thereby limit systematic effects. Cancer therapy via MNPs proposes novel properties rather than normal methods such as almost zero side effects and a high-efficiency rate of effectiveness. The key aim of targeted drug delivery is to reduce side effects of the main cancer treatment that other usual chemotherapies will attend to the body, and thus controlling the effectiveness of the drug on a specific location that tumoral tissue exist. Herein, the high potential of MNPs has been studied, and different examples of their effectiveness on drug delivery and hypothermia therapy have been provided.



中文翻译:

磁性纳米粒子化学修饰用于癌症化疗中靶向药物输送的最新趋势

如今,由于磁性纳米颗粒(MNP)作为治疗热疗的热介质的巨大潜力以及在特定位置递送药物的可能性,因此磁性纳米颗粒(MNP)已被迅速研究并引起了全世界的关注,从而限制了系统的作用。通过MNP进行的癌症治疗提出了新颖的特性,而不是常规方法,例如几乎零副作用和高效率。靶向药物输送的主要目的是减少其他常见化学疗法会进入人体的主要癌症治疗的副作用,从而在存在肿瘤组织的特定位置控制药物的有效性。在此,已经研究了MNP的高潜力,并且提供了其在药物递送和低温治疗中的有效性的不同实例。

更新日期:2020-04-20
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