ABSTRACT A simple, highly efficient and green three-component condensation for synthesis of 2-substituted-3-(2-oxoalkyl)isoindolin-1-one derivatives from phthalaldehydic acid, primary amine, and ketone in the presence thiamine hydrochloride (VB1) as catalyst in water has been developed. Their activities have also shown inhibition activity against HeLa, A549, and Hep2 cancer cell lines. The results showed that some synthesized isoindolin-1-one derivatives have exhibited cytotoxic activity on HeLa, A549, and Hep-2 cancer cell lines at µg/mL concentrations.

中文翻译：

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以盐酸硫胺素 (VB1) 为催化剂的 Isoindolin-1-ones 的一锅合成及其对癌细胞系的抑制活性

摘要 在硫胺素盐酸盐 (VB1) 存在下，一种简单、高效、绿色的三组分缩合反应，用于由邻苯二甲酸、伯胺和酮合成 2-取代-3-(2-氧代烷基)异吲哚啉-1-酮衍生物已研制出水中催化剂。它们的活性还显示出对 HeLa、A549 和 Hep2 癌细胞系的抑制活性。结果表明，一些合成的 isoindolin-1-one 衍生物在 µg/mL 浓度下对 HeLa、A549 和 Hep-2 癌细胞系表现出细胞毒活性。