ABSTRACT The molar solubility of celecoxib (CXB) was measured in the binary mixtures of 1-propanol + water at temperatures ranging from 293.2 to 313.2 K. The obtained solubility data are mathematically represented by employing five cosolvency models (i.e. van’t Hoff equation, Yalkowsky–Roseman model, Jouyban–Acree model, Jouyban–Acree–van’t Hoff model and the modified Wilson model), and the mean relative deviations (MRD%) calculated for the back-calculated solubility data were 2.5%, 68.7%, 12.7%, 12.8% and 20.5%, respectively, for each investigated cosolvency model. The apparent dissolution enthalpy, entropy and Gibbs energy of CXB in these solvent mixtures were also computed based on the van’t Hoff and Gibbs equations.

中文翻译：

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塞来昔布在 1-丙醇 + 水混合物中的溶解度 T= (293.2–313.2) K：实验数据和热力学分析

摘要 在 1-丙醇 + 水的二元混合物中，在 293.2 至 313.2 K 的温度范围内测量了塞来昔布 (CXB) 的摩尔溶解度。获得的溶解度数据通过使用五个共溶解度模型（即 van't Hoff 方程， Yalkowsky-Roseman 模型、Jouyban-Acree 模型、Jouyban-Acree-van't Hoff 模型和修正的 Wilson 模型），并且为反向计算的溶解度数据计算的平均相对偏差（MRD%）分别为 2.5%、68.7%、对于每个研究的共偿能力模型，分别为 12.7%、12.8% 和 20.5%。CXB 在这些溶剂混合物中的表观溶解焓、熵和 Gibbs 能量也基于 van't Hoff 和 Gibbs 方程计算。