Abstract Poloxamer (Pluronic®) and poloxamine (Tetronic®) are commercially important block copolymers composed of polypropylene oxide (PPO) and polyethylene glycol (PEG) segments. Due to the difference in chemical polarity of the two blocks, the copolymers exhibit amphiphilicity and thermally induced aggregation behavior in aqueous solutions. The present work shows that block copolymer architecture is not necessary to achieve an amphiphilic character in PPO and PEG-based polymers. Instead a simple molecular tweaking by adding a very short hydrophilic or hydrophobic side-chain allows for attaining amphiphilicity and consequential thermoresponsiveness in PEG and PPO-rich polymers.

中文翻译：

---

解构泊洛沙姆和泊洛沙胺嵌段共聚物以获得基于聚（乙二醇）和聚（环氧丙烷）的热响应聚合物

摘要 泊洛沙姆 (Pluronic®) 和泊洛沙胺 (Tetronic®) 是商业上重要的嵌段共聚物，由聚环氧丙烷 (PPO) 和聚乙二醇 (PEG) 链段组成。由于两个嵌段的化学极性不同，共聚物在水溶液中表现出两亲性和热诱导聚集行为。目前的工作表明，嵌段共聚物结构对于在 PPO 和基于 PEG 的聚合物中实现两亲特性不是必需的。相反，通过添加非常短的亲水或疏水侧链进行简单的分子调整，可以在 PEG 和 PPO 富含聚合物中实现两亲性和相应的热响应性。